A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2710835
The invention provides fibronectin-based binding molecules and methods for introducing donor CDRs into a fibronectin--based binding scaffold, in particular, Fn3. The fibronectin-based binding molecules of the invention may be further conjugated to another moiety, for example, Fc, anti-FcRn, HSA, anti-HSA, and PEG, for improved half life and stability, particularly in mammalian cells. The invention also provides methods for screening such molecules for binding to a target anti-gen as well as the manufacture and purification of a candidate binder.
La présente invention concerne des molécules fibronectine améliorées de liaison et des procédés permettant l'introduction de régions déterminant la complémentarité de donneur dans un échafaudage de liaison à base de fibronectine, notamment, la Fn3. Les molécules de liaison à base de fibronectine selon l'invention peuvent également être conjuguées à un autre groupe fonctionnel, par exemple, Fc, anti-FcRn, HSA, anti-HSA, et PEG, pour une demi-vie et une stabilité améliorées, en particulier dans des cellules mammaliennes. L'invention concerne également des procédés de criblage de telles molécules pour la liaison à un antigène cible ainsi que la fabrication et la purification d'un liant candidat.
Brannetti Barbara
Ewert Stefan
Kolbinger Frank
Vincent Karen Jane
Fetherstonhaugh & Co.
Novartis Ag
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