Improved forms of basic fibroblast growth factor

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/50 (2006.01) A61K 38/18 (2006.01) A61K 47/18 (2006.01) C07K 1/113 (2006.01) C07K 1/16 (2006.01)

Patent

CA 2055462

2055462 9013310 PCTABS00002 Treatment of basic fibroblast growth factor (bFGF) with organic disulfides, preferably glutathione disulfide, or with inorganic compounds of similar function results in a bFGF composition of enhanced stability and resistance to multimerization. The resulting stabilized form mimics the chromatographic behavior of bFGF as isolated from bovine pituitary.

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