Improved formulations for poorly permeable active...

A - Human Necessities – 61 – K

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Details

A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2720658

The present invention relates to a pharmaceutical oral dosage form containing a poorly permeable active pharma-ceutical ingredient and at least one permeability improving substance, wherein the permeability improving substance is ther-mostably embedded in a water-soluble matrix of a water soluble carrier, and to thermostable formulations which can be used to improve bioavailability.

La présente invention porte sur une forme dosifiée orale pharmaceutique contenant un ingrédient pharmaceutique actif faiblement perméable et au moins une substance améliorant la perméabilité, la substance améliorant la perméabilité étant noyée de façon thermiquement stable dans une matrice hydrosoluble constituée d'un véhicule hydrosoluble. L'invention porte également sur des formulations thermiquement stables qui peuvent être utilisées pour améliorer la biodisponibilité.

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