Improved formulations of fenofibrate containing menthol or...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/216 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2601372

The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of fenofibrate or another fibrate drug intimately associated with menthol, optionally in the presence of at least one surfactant mixture. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject a composition comprising a therapeutically effective amount of fenofibrate or another fibrate drug and menthol or PEG/poloxamer (preferably PEG 1000 and Poloxamer 407), wherein the fenofibrate or the other fibrate drug is in intimate association with the menthol or PEG/poloxamer, wherein the menthol can be menthol or menthol surfactant mixture.

L'invention concerne au moins une composition pour le traitement de taux élevés de triglycérides, comprenant une quantité thérapeutiquement efficace de fénofibrate ou d'un autre médicament à base de fibrate intimement associé au menthol, en option avec la présence d'au moins un mélange de surfactant. L'invention concerne aussi un procédé pour le traitement de taux élevés de triglycérides chez un sujet, comprenant l'administration à ce dernier d'une composition comprenant une quantité thérapeutiquement efficace de fénofibrate ou d'un autre médicament à base de fibrate et de menthol ou d'un PEG/poloxamère (de préférence PEG 1000 et le poloxamère 407), dans lequel le fénofibrate ou l'autre médicament à base de fibrate est associé intimement au menthol ou au PEG/poloxamère, lequel menthol peut être du menthol ou un mélange de surfactant avec du menthol.

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