Improved gene silencing methods

Details Improved gene silencing methods Improved gene silencing methods

C - Chemistry, Metallurgy

12

N

C12N 5/14 (2006.01) C12N 15/29 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2650861

Methods and means are provided to modulate gene silencing in eukaryotes through the alteration of the functional level of particular DICER or DICER like proteins. Also provided are methods and means to modulate post-transcriptional gene silencing in eukaryotes through the alteration of the functional level of proteins involved in transcriptional silencing of the silencing RNA encoding genes.

L'invention concerne des procédés et des moyens de modulation du silençage de gènes chez des eucaryotes par modification du niveau fonctionnel d'un DICER spécifique ou de protéines de type DICER spécifiques. L'invention concerne également des procédés et des moyens de modulation du silençage post-transcriptionnel de gènes chez des eucaryotes par modification du niveau fonctionnel de protéines impliquées dans le silençage transcriptionnel des gènes codant pour l'ARN interférant.

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