Improved halohydrin dehalogenases and related polynucleotides

Details Improved halohydrin dehalogenases and related polynucleotides Improved halohydrin dehalogenases and related polynucleotides

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12N 15/60 (2006.01)

Patent

CA 2535255

The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

L'invention concerne de nouveaux polypeptides de déshalogénase d'halohydrine et les polynucléotides codant ces polypeptides. Lesdits polypeptides servent à la fabrication de dérivés d'acide 3-butyrique-4-substitué, et d'esters d'acide cyano carboxylique vicinal à substitution hydroxyl. L'invention concerne également des vecteurs, des cellules hôtes et des procédés correspondants.

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