Improved heat shock protein-based vaccines and immunotherapies

Details Improved heat shock protein-based vaccines and immunotherapies Improved heat shock protein-based vaccines and immunotherapies

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 5/068 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 5/107 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2521809

Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.

La présente invention concerne des antigènes hybrides comportant au moins un domaine antigénique, au moins un domaine de liaison à des protéines de choc thermique, et au moins un lieur peptidique amélioré entre les deux domaines, lesdits antigènes s'avérant utiles pour l'induction d'une réponse immunitaire vis-à-vis du domaine antigénique lorsqu'ils sont administrés seuls ou dans un complexe avec au moins une protéine de choc thermique. Ces antigènes hybrides et les complexes associés peuvent être utilisés pour traiter des maladies infectieuses et des cancers qui expriment un antigène du domaine antigénique.

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