A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61L 27/20 (2006.01) A61L 27/38 (2006.01) A61L 27/52 (2006.01) A61L 31/00 (2006.01) A61L 31/14 (2006.01)
Patent
CA 2274661
This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.
L'invention porte sur des compostions destinées à être implantées chez un animal et comprenant un polymère biodégradable, biocompatible, qui forme un hydrogel lors de la réticulation. Selon un mode préféré, le polymère est réticulé par des ions multivalents, plus souhaitablement, un sel soluble d'un ion multivalent et un sel modérément soluble d'un ion multivalent, ces composants étant combinés pour obtenir un mélange formant un hydrogel injectable, partiellement durci, la consistance du mélange étant appropriée pour implanter le mélange d'hydrogel partiellement durci chez un animal. Cet hydrogel implanté, partiellement durci, forme in situ un hydrogel totalement durci. De préférence, le mélange contient également un agent séquestrant biocompatible qui rivalise avec le polymère biocompatible dans la liaison de l'ion de réticulation multivalent. Cette composition peut ou peut ne pas contenir de cellules vivantes. L'invention porte également sur des procédés d'implantation de la composition chez un animal, celle-ci pouvant être un implant contenant des cellules vivantes.
Borland Kermit M.
Nelson Gordon P.
Omstead Daniel R.
Zhou Tao
Curis Inc.
Mbm & Co.
Reprogenesis Inc.
LandOfFree
Improved hydrogel for tissue engineering does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Improved hydrogel for tissue engineering, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved hydrogel for tissue engineering will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1529600