A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61L 31/00 (2006.01)
Patent
CA 2304093
This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.
L'invention concerne des compositions conçues pour être implantées chez l'animal et contenant un polymère biocompatible et biodégradable dont la réticulation crée un hydrogel. Dans un mode de réalisation préféré, ce polymère est réticulé par des ions multivalents, de préférence, par un sel soluble d'un ion multivalent et un sel passablement soluble d'un ion multivalent, ces constituants étant combinés en un mélange constituant un hydrogel injectable partiellement durci, la consistance de ce mélange permettant d'implanter ce dernier chez l'animal, dans lequel il forme in situ un hydrogel totalement durci. Ce mélange contient également, de préférence, un agent séquestrant en concurrence avec le polymère biocompatible afin de fixer l'ion multivalent de réticulation. Cette composition peut contenir des cellules vivantes ou non. Elle concerne également des procédés servant à implanter cette composition chez l'animal sous forme éventuelle d'implant contenant des cellules vivantes.
Borland Kermit M.
Nelson Gordon P.
Omstead Daniel R.
Zhou Tao
Curis Inc.
Mbm Intellectual Property Law Llp
Reprogenesis Inc.
LandOfFree
Improved hydrogel for tissue engineering does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Improved hydrogel for tissue engineering, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved hydrogel for tissue engineering will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2083150