A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2407303
This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral vaccine, e.g., a poxvirus vaccine, to potentiate and broaden the immune response. The present invention further provides a particularly effective vaccine regimen comprising a DNA vaccine used in combination with a poxvirus virus, especially NYVAC or ALVAC.
L'invention se rapporte à des procédés améliorés permettant d'induire une réponse immunitaire afin de prévenir ou de traiter l'infection par le VIH-1 au moyen d'un vaccin à base d'acides nucléiques en association avec un vaccin antiviral de recombinaison, par exemple, un vaccin contre un poxvirus, de manière à potentialiser et élargir la réponse immunitaire. La présente invention se rapporte également à un schéma posologique pour vaccin particulièrement efficace comportant l'administration d'un vaccin à base d'ADN en association avec un virus de type poxvirus, notamment NYVAC ou ALVAC.
Franchini Genoveffa
Hel Zdenek
Pavlakis George
Tartaglia James
Aventis Pasteur Inc.
Fetherstonhaugh & Co.
The Government Of The United States Of America
LandOfFree
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