Improved immunotherapy

Details Improved immunotherapy Improved immunotherapy

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/167 (2006.01) A61K 31/396 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01) C07K 14/195 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 9/06 (2006.01) C12N 15/12 (2006.01) C12N 15/53 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2500336

The invention provides an improved method of inducing an immune response against targeted cells. Using gene therapy to express both a toxin or prodrug converting enzyme as a means of killing a targeted cell type and also stress response protein (in particular, a heat shock protein) enhances the subsequent immune response directed against such cells. The method is particularly applicable to inducing an immune response against cancer cells. Also provided are polynucleotides, products and vectors for use in such a method.

L'invention concerne un procédé amélioré permettant d'induire une réponse immunitaire contre des cellules ciblées. L'utilisation de la thérapie génique pour exprimer une toxine ou une enzyme de conversion de promédicament en tant que moyen d'élimination d'un type de cellule ciblée et également une protéine de réponse au stress (en particulier, une protéine de choc thermique) améliore la réponse immunitaire subséquente dirigée contre lesdites cellules. Ce procédé s'avère particulièrement utile pour induire une réponse immunitaire contre des cellules cancéreuses. L'invention concerne également des polynucléotides, des produits et des vecteurs destinés à être utilisés dans ledit procédé.

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