Improved inhibition of graft versus host disease

Details Improved inhibition of graft versus host disease Improved inhibition of graft versus host disease

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61P 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2297448

The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, in admixture with red blood cells of the donor, extracorporeally, to oxidative stress, in appropriate dosage amounts, such as bubbling a gaseous mixture of ozone and oxygen through a suspension of the T-cells. The process may also include irradiation of the cells with UV light, simultaneously with the application of the oxidative stress. After stressing, the T- cell composition is aged at reduced temperatures for at least 6 hours, before being administered to the patient. The oxidative stress induces reduced inflammatory cytokine production and a reduced proliferative response in the T-cells.

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