Improved injection system

A - Human Necessities – 61 – M

Patent

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Details

A61M 5/32 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2494316

Novel methods of injecting agents including cells into organs, tissues, or tumors using a side release needle and, optionally, a carrier that aids in retention of the cells at the injection site, or a tissue sealant or film to seal the injection site are provided. The use of side release needles and, optionally, a carrier, sealant, or film prevents the leakage of the injected agent back out of the injection site. Agents which maybe injected using the inventive method include drugs, small molecules, peptides, proteins, polynucleotides, viruses, cells, etc. Any type of cells including myoblasts may be used in the invention. The cells may be injected into any organ including the heart, brain, pancreas, liver, etc.. These injection methods may find use in tissue engineering, gene therapy, and tissue/organ repair. Kits with the side release needles used in carrying out the present invention are also provided.

L'invention concerne de nouveaux procédés d'injection d'agents incluant des cellules, dans des organes, des tissus ou des tumeurs au moyen d'une aiguille à libération latérale, et, éventuellement, d'un excipient facilitant la rétention des cellules au site d'injection, ou d'un agent d'obturation de tissu ou d'un film pour obturer le site d'injection. L'utilisation d'aiguilles à injection latérale, et, éventuellement d'un excipient, d'un agent d'obturation ou d'un film permet d'éviter toute fuite de l'agent injecté hors du site d'injection. Les agents pouvant être injectés à l'aide du procédé de l'invention comprennent des médicaments, de petites molécules, des peptides, des protéines, des polynucléotides, des virus, des cellules, etc.. N'importe quel type de cellule, y compris des myoblastes, peut être utilisé dans l'invention. Les cellules peuvent être injectées dans un organe tel que le coeur, le cerveau, le pancréas, le foie, etc.. Ces procédés d'injection peuvent être utiles dans la mise au point génétique de tissus, la thérapie génique et/ou la réparation de tissus/d'organe. L'invention concerne aussi des trousses qui comprennent lesdites aiguilles servant à mettre en oeuvre l'invention.

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