Improved interferon polymer conjugates

Details Improved interferon polymer conjugates Improved interferon polymer conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/21 (2006.01) C07K 14/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176229

A process is disclosed for preparing long-acting alpha interferon-containing compositions. Alpha interferon is contacted with a relatively small molar excess of a substantially non-antigenic polymer in the presence of a surfactant to preserve bioactivity. Isolation of the desired conjugate species having optimal activity is also disclosed.

On décrit un procédé de préparation de compositions à effet prolongé contenant l'interféron alpha. L'interféron alpha est mis en contact avec un excès molaire relativement faible d'un polymère essentiellement non antigène, en présence d'un tensioactif, pour conserver la bioactivité. On décrit également une purification du produit de conjugaison pour obtenir un produit souhaité ayant une activité optimale.

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