A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/21 (2006.01) A61K 47/48 (2006.01) C07K 1/113 (2006.01) C07K 14/56 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2268433
32 Compositions containing alpha interferon conjugated to a substantially non- antigenic polymer are disclosed in which at least about 30% o of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate- activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.
L'invention concerne des compositions contenant de l'interféron alpha conjuguées à un polymère sensiblement non antigénique dans lesquelles au moins environ 30 % des conjugués comprennent une fixation covalente de l'inteféron alpha au polymère sensiblement non antigénique au niveau d'une histidine. L'invention concerne également un procédé de préparation des conjugués. Le procédé consiste à mettre un interféron alpha en contact avec un polymère sensiblement non antigénique activé par du carbonate de succinimidyle à un pH suffisant pour faciliter la fixation covalente du polymère sur une histidine de l'interféron alpha.
Gilbert Carl W.
Park-Cho Myung-Ok
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Inc.
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