Improved mammalian expression vectors and uses thereof

Details Improved mammalian expression vectors and uses thereof Improved mammalian expression vectors and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2711962

The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., COS7 or HEK293-6E cells). The methods and systems are useful, for example, in pharmaceutical drug development and cloning, especially for the production of antibodies.

L'invention concerne des acides nucléiques pour une expression de protéine recombinante dans une culture cellulaire de mammifère. Les vecteurs épisomaux selon l'invention favorisent une production élevée de protéine dans des cellules de mammifère exprimant SV40 T Ag ou l'antigène nucléaire du virus d'Epstein-Barr ou (par exemple, des cellules COS7 HEK293-6E). Les procédés et les systèmes sont utiles par exemple dans le développement de médicaments pharmaceutiques et le clonage, particulièrement, pour la production d'anticorps.

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