Improved mass spectrometric analysis using nanoparticles

Details Improved mass spectrometric analysis using nanoparticles Improved mass spectrometric analysis using nanoparticles

G - Physics

01

N

G01N 33/543 (2006.01)

Patent

CA 2457945

The invention relates to an improved method for mass spectrometric analysis, especially for matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF-MS), using nanoparticles. An analyte is added to a nanoparticle suspension and the suspension containing the bound analyte is then deposited directly on a MALDI sample carrier and is analysed by mass spectrometry. The invention also relates to nanoparticles which are suitable for said method.

L'invention concerne un procédé amélioré d'analyse spectrométrique de masse, s'utilisant notamment pour la spectrométrie de masse du temps de vol de désorption/ionisation par impact laser assistée par matrice (MALDI-TOF-MS), à l'aide de nanoparticules. Un analyte est ajouté à une suspension de nanoparticules et la suspension contenant l'analyte lié est ensuite précipitée directement sur un porte-échantillons MALDI et est examinée par spectrométrie de masse. L'invention concerne en outre les nanoparticules appropriées pour ce procédé.

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