Improved method for c-terminal degradation of peptides and...

Details Improved method for c-terminal degradation of peptides and... Improved method for c-terminal degradation of peptides and...

C - Chemistry, Metallurgy

07

K

C07K 1/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2290650

A method for C-Terminal degradation of peptides and proteins involves forming a thiohydantoin derivative of the C-Terminal amino acid and then cleaving the derivatized amino acid by reaction with methoxide or methiolate ions.

L'invention concerne un procédé permettant la dégradation sur terminaison C de peptides et de protéines, lequel procédé consiste à former un dérivé thiohydantoïne de l'aminoacide à terminaison C, puis à cliver l'aminoacide modifié par réaction avec des ions méthoxyde ou méthiolate.

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