Improved method for making analgesics

Details Improved method for making analgesics Improved method for making analgesics

C - Chemistry, Metallurgy

07

D

C07D 489/08 (2006.01) A61K 31/33 (2006.01)

Patent

CA 2672644

Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.

L'invention concerne un chlorhydrate d'oxymorphone analgésique amélioré contenant moins de 10 ppm de cétones alpha béta insaturées, ainsi que des préparations pharmaceutiques comprenant un tel chlorhydrate d'oxymorphone. Le chlorhydrate d'oxymorphone est produit en réduisant un produit de départ de chlorhydrate d'oxymorphone au moyen d'hydrogène gazeux, et dans des conditions spécifiées d'acidité, de système de solvant et de température. Un polymorphe spécifique du chlorhydrate d'oxymorphone peut être obtenu par hydratation.

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