C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/12 (2006.01) C07D 207/277 (2006.01) C07D 207/36 (2006.01) C07D 207/38 (2006.01) C07D 261/02 (2006.01)
Patent
CA 2568836
A process for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).
Cette invention porte sur un procédé de préparation de (3<I>R</I>,4<I>R</I>)-3-hydroxy-4-hydroxyméthylpyrrolidine, composé représenté par la formule (I), ou de (3<I>S</I>,4<I>S</I>)-3-hydroxy-4-hydroxyméthylpyrrolidine, composé représenté par la formule (Ia), lequel procédé comprend, comme étape clé, l'hydrolyse énantiosélective catalysée par des enzymes d'un composé racémique pyrrolidinone 3,4-trans-disubstitué représenté par la formule (II).
Clinch Keith
Evans Gary Brian
Lenz Dirk Henning
Mason Jennifer Mary
Tyler Peter Charles
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Industrial Research Limited
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