Improved method for preparing 1,3-disubstituted pyrrolidine...

Details Improved method for preparing 1,3-disubstituted pyrrolidine... Improved method for preparing 1,3-disubstituted pyrrolidine...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01)

Patent

CA 2662839

A process for preparing substituted pyrrolidine compounds, including (5)-2-{l-[2- (2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide, commonly known in the art as darifenacin, comprising reacting a pyrrolidine compound with a benzofuran derivative in the presence of a phase-transfer catalyst.

L'invention concerne un procédé pour préparer des composés de pyrrolidine substituée, comprenant le bromhydrate de (5)-2-{l-[2-(2,3-dihydrobenzofuran-5-yl)éthyl]-3-pyrrolidinyl}-2,2-diphénylacétamide, couramment connu dans l'art en tant que darifénacine, comprenant la réaction d'un composé pyrrolidine avec un dérivé du benzofurane en présence d'un catalyseur de transfert de phase.

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