Improved method for preparing opipramol

Details Improved method for preparing opipramol Improved method for preparing opipramol

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) C07D 223/22 (2006.01) C07D 223/26 (2006.01)

Patent

CA 2204261

An improved method for preparing opipramol is disclosed, wherein iminostilbene is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase transfer agent to produce N-(3-halopropyl)iminostilbene, which is mixture of N-(3- chloropropyl)iminostilbene and N-(3-bromopropyl)iminostilbene, and then N-(3-halopropyl)iminostilbene is reacted with N-(2-hydroxyethyl)piperazine to form opipramol.

L'invention présente un procédé amélioré de préparation d'opipramol, consistant à faire réagir de l'iminostilbène avec du 1-bromo-3-chloropropane, en présence d'une base faible sélectionnée à partir d'un sel d'hydrogéno-phosphate ainsi que d'un sel d'acétate, et en présence d'un agent de transfert de phase, afin de produire du N-(3-halopropyl)iminostilbène, lequel est un mélange de N-(3-chloropropyl)iminostilbène et de N-(3-bromopropyl)iminostilbène. On fait alors réagir le N-(3-halopropyl)iminostilbène avec de la N-(2-hydroxyethyl) piperazine pour obtenir de l'opipramol.

Affiliated with

Also associated with

Rating

Improved method for preparing opipramol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Improved method for preparing opipramol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved method for preparing opipramol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1454167