Improved method for production of secreted proteins in fungi

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/80 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2438356

This invention relates to a promoter and to a fungal host for improved protein production. According to the invention the promoter has been modified in its response to the mechanisms mediating transcriptional down-regulation of secreted proteins under secretion stress. This invention relates also to methods for optimised protein production of secretable proteins in fungi.

L'invention concerne un promoteur et un hôte fongique pour une production améliorée de protéines. Le promoteur a été modifié dans sa réponse aux mécanismes induisant la régulation négative de protéines sécrétées sous stress de sécrétion. L'invention concerne également des procédés de production optimisée de protéines pouvant être sécrétées dans les champignons.

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