Improved method for the production of bacterial toxins

Details Improved method for the production of bacterial toxins Improved method for the production of bacterial toxins

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) C07K 1/22 (2006.01) C07K 7/08 (2006.01) C07K 14/235 (2006.01) C12N 1/20 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2405035

Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are provided including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.

L'invention concerne des méthodes et des compositions pour la production améliorée de toxines bactériennes dans des cultures à grande échelle. D'une manière spécifique, l'invention concerne des méthodes et des compositions permettant de réduire les inhibiteurs de l'expression des toxines bactériennes, ces méthodes consistant notamment à ajouter des composés se liant aux inhibiteurs de l'expression des toxines bactériennes, à utiliser des milieux de culture ayant des concentrations réduites de précurseurs métaboliques des inhibiteurs de toxines et de bactéries toxogènes génétiquement modifiées dépourvues des enzymes nécessaires à la métabolisation des précurseurs métaboliques des inhibiteurs de toxines.

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