C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01)
Patent
CA 2746386
The present invention relates to processes for preparing indoline compounds, comprising the steps of:a) reacting formula (I) and formula (II) to form a hydrazone; b) cyclization of the hydrazone in the presence of a Fischer catalyst to form a 3H-indole; c) reduction of the 3H-indole to form a 2,3-dihydro-indole; d) nitration of the 2,3-dihydro-indole to form a 6-nitro-2,3- dihydro-indole; e) acylation of the 6-nitro-2,3-dihydro-indole to form the protected 6-nitro-2,3- dihydro-indole; and f) conversion of the nitro group to form 6-amino-2,3-dihydro-indole.
La présente invention porte sur des procédés de préparation de dérivés indolines, en particulier du 1-acétyl-6-amino-3,3-diméthyl-2,3-dihydroindole.
King Anthony
Larsen Robert
Li Tj
Lu Yuelie
Amgen Inc.
Gowling Lafleur Henderson Llp
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