A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2258515
The present invention relates to treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs and other altered antibodies such as Fabs, chimeric, human and humanized antibodies that do not block binding of human IL-5 to the .alpha.-chain of the human IL-5 receptor.
La présente invention se rapporte au traitement et au diagnostic des troubles véhiculés par IL-5 et par la production excessive d'éosinophiles et, plus particulièrement, aux mAbs et à d'autres anticorps altérés tels que les fragments Fab, les anticorps chimères et les anticorps humains ou humanisés qui ne bloquent pas la liaison d'IL-5 humaine à la chaîne .alpha. du récepteur humain d'IL-5.
Appelbaum Edward Robert
Cook Richard Murray
Glaxosmithkline Llc
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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