Improved method of production of pneumococcal surface proteins

Details Improved method of production of pneumococcal surface proteins Improved method of production of pneumococcal surface proteins

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2304128

The present invention provides improved methods for preparation of immunoligical or vaccine compositions comprising PspA-like polypeptides. Specifically, the present invention provides vaccine compositions wherein PspA or PspA-like polypeptide from Rx1 or other representatives of clade 2 or family 1 have been produced by recombinant methods. Recombinant constructs are provided which express a substantially homogeneous, truncated form of immunologically active PspA-like polypeptides in host cells transformed with such constructs.

Cette invention concerne des procédés améliorés permettant de préparer des compositions immunologiques ou vaccinales contenant des polypeptides du type PspA. D'une manière plus spécifique cette invention concerne des compositions vaccinales dans lesquelles le polypeptide PspA ou du type PspA provenant de Rx1 ou d'autres représentants du clade 2 ou de la famille 1 ont été produits au moyen de procédés de recombinaison. On décrit des structures de recombinaison qui expriment une forme tronquée, sensiblement homogène de polypeptides du type PspA actifs du point de vue immunologique dans des cellules hôtes transformées avec ces mêmes structures.

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