Improved methods and compositions for determining the...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) C12N 15/65 (2006.01)

Patent

CA 2682921

Methods and compositions for the detection of disease caused by infectious agents and microbes are provided. In particular, methods and compositions comprising novel combinations of nucleic acid amplification and drug susceptibility technologies are provided. In certain embodiments, the present invention enables the detection of infectious agents and microbes as well as providing information concerning the viability status of the agent or microbe. In one embodiment, the present invention is used for the detection of mycobacterial infections, including, but not limited to, tuberculosis.

L'invention concerne des procédés et des compositions pour la détection d'une maladie provoquée par des agents infectieux et des microbes. En particulier, l'invention concerne des procédés et des compositions comprenant de nouvelles combinaisons de technologies d'amplification d'acide nucléique et de sensibilité à un médicament. Dans certains modes de réalisation, la présente invention permet la détection d'agents infectieux et de microbes ainsi que la fourniture d'informations concernant l'état de viabilité de l'agent ou du microbe. Dans un mode de réalisation, la présente invention est utilisée pour la détection d'infections mycobactériennes, comprenant, mais sans s'y limiter, la tuberculose.

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