Improved methods and compositions for rna interference

Details Improved methods and compositions for rna interference Improved methods and compositions for rna interference

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01N 43/54 (2006.01) A01N 43/90 (2006.01) A01P 1/00 (2006.01) A01P 3/00 (2006.01) A01P 5/00 (2006.01) A01P 7/00 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/79 (2006.01) C12Q 1/02 (2006.01) C40B 30/06 (2006.01) C40B 40/02 (2006.01)

Patent

CA 2545182

The invention relates to improved methods of attenuating expression of a target gene in a eukaryotic cell with dsRNA, identifying nucleic acid sequences responsible for conferring a particular phenotype to a cell, alleviating pest infestation in plants, and altering gene expression in an undifferentiated stem cell or the differentiated progeny thereof. Transcription of the RNA, which will form the dsRNA, is terminated by one or more terminators sequences, thereby increasing the efficiency of inhibition.

L'invention concerne des méthodes améliorées servant à atténuer l'expression d'un gène ciblé dans une cellule eucaryote possédant ARNds, identifier des séquences d'acide nucléique conférant un génotype spécifique à une cellule, lutter contre les attaques des insectes nuisibles chez la plante et modifier l'expression génique dans une cellule souche indifférenciée ou dans sa descendance différenciée. La transcription de l'ARN, qui constituera l'ARNds, est terminée par une ou plusieurs séquences de terminaison, ce qui permet d'augmenter l'efficacité de l'inhibition.

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