Improved methods and devices for delivering a therapeutic...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12M 1/42 (2006.01)

Patent

CA 2604452

The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and/or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration, their preparation and uses.

La présente invention concerne, globalement, des améliorations apportées à des méthodes destinées à l'administration d'un agent bioactif, en particulier un acide nucléique thérapeutique ou prophylactique, à la sphère oculaire d'un patient. Ces méthodes consistent à administrer ledit agent aux tissus ou aux cellules du corps ciliaire et/ou aux tissus ou aux cellules des muscles extra-oculaires. Plus particulièrement, l'invention concerne des dispositifs, leurs applications, notamment en thérapie génique, ainsi que des méthodes, destinés au traitement de pathologies de la sphère oculaire. Ces méthodes consistent à administrer un produit thérapeutique et à transférer ce dernier dans le tissu oculaire à traiter, par l'intermédiaire de tissus ou de cellules spécifiques du corps ciliaire et/ou de tissus ou de cellules spécifiques des muscles extra-oculaires. La présente invention concerne également des compositions pharmaceutiques comprenant le produit sous une forme qui convient pour être administré aux tissus ou aux cellules du corps ciliaire et/ou aux tissus ou aux cellules des muscles extra-oculaires, la préparation de ces compositions et leurs applications.

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