C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/00 (2006.01) C07K 14/335 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2450318
The invention provides a method for binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium, said substance comprising an AcmA cell wall binding domain or homolog or functional derivative thereof, said method comprising treating said cell-wall material with a solution capable of removing a cell-wall component such as a protein, (lipo) teichoic acid or carbohydrate from said cell-wall-material and contacting said substance with said cell-wall material.
La présente invention concerne une technique permettant d'améliorer la liaison d'une substance protéinique à la paroi cellulaire d'une bactérie Gram positif, cette substance comprenant un domaine de fixation de paroi de cellule AcmA ou un homologue ou un dérivé fonctionnel de celui-ci. Cette technique consiste à traiter cette paroi cellulaire avec une solution capable de retirer un élément de cette paroi cellulaire tel qu'une protéine, un acide (lipo)teichoique ou un élément glucidique de cette paroi et de mettre en contact cette substance avec cette paroi cellulaire.
Buist Girbe
Kok Jan
Kuipers Oscar Paul
Leenhouts Cornelis Johannes
Ramasamy Ranjan
Applied Nanosystems B.v.
Fetherstonhaugh & Co.
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