C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 41/00 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2742295
Enveloped virus-based virus-like particles (VLPs) that are free of infectious agents and substantially as immunogenic as corresponding VLPs prior to inactivation of infectious agents are described. Improved methods of inactivation infectious agents in preparations of enveloped virus-based VLPs are also described wherein the methods do not adversely affect the immunogenicity of the VLPs.
L'invention porte sur des particules de type virus (VLP) basées sur des virus à enveloppe qui sont exempts d'agents infectieux et sensiblement aussi immunogènes que les VLP correspondants avant l'inactivation des agents infectieux. Des procédés perfectionnés d'inactivation des agents infectieux dans des préparations de VLP basées sur des virus à enveloppe sont également décrits, les procédés n'affectant pas de façon défavorable l'immunogénicité des VLP.
Haynes Joel R.
Taylor Ross
Gowling Lafleur Henderson Llp
Ligocyte Pharmaceuticals Inc.
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