Improved methods of delivery using cationic lipids and...

Details Improved methods of delivery using cationic lipids and... Improved methods of delivery using cationic lipids and...

A - Human Necessities

61

K

167/163

A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2286739

Methods and compositions are provided for the introduction of polyanionic molecules, in particular, nucleic acids, into mammalian cells using certain phosphatidyl ethanolamines as helper lipids in conjunction with various cationic lipids. In particular, cationic lipid-mediated transfection of mammalian cells is improved by the use of lipid carriers comprising DLPE or DiPPE and cationic lipids.

L'invention concerne des méthodes et des compositions pouvant être utilisées pour introduire des molécules polyanioniques, en particulier des acides nucléiques, dans des cellules mammaliennes, en utilisant certains phosphatidyl éthanolamines comme lipides assistants conjointement avec divers lipides cationiques. En particulier, on améliore la transfection de cellules mammaliennes induite par des lipides cationiques en utilisant des supports lipidiques comprenant 1,2-dilauroyl-sn-glycéro-3-phosphoéthanolamine (DLPE) ou 1,2-diphytanoyl-sn-glycéro-3-phosphoéthanolamine (DiPPE) et des lipides cationiques.

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