C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01)
Patent
CA 2659945
This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
Cette invention concerne, de manière générale, des procédés d'obtention de cellules et de tissus mammifères avec des motifs d'expression génétique semblables à ceux de l'embryon ou du foetus du mammifère en développement et l'utilisation de ces cellules et tissus dans le traitement de maladies et pathologies humaines liées au vieillissement. L'invention, concerne, plus particulièrement, des procédés d'identification, d'expansion en culture et de formulation de cellules souches pluripotentes mammifères et de cellules différenciées différentes des cellules chez l'adulte humain en termes de motif d'expression génétique, d'où leurs caractéristiques uniques permettant l'application de nouvelles stratégies thérapeutiques dans le traitement de maladies dégénératives.
Chapman Karen B.
Sargent Roy Geoffrey
West Michael D.
Advanced Cell Technology Inc.
Gowling Lafleur Henderson Llp
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