A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01) A61K 9/51 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2739499
The present invention relates to a method for the production of a nanoparticulate pharmaceutical composition. The method comprises the steps of a) suspending in water a poorly soluble active ingredient without the presence of a detergent, b) mechanically treating said suspension to obtain particles comprising the active ingredient with an effective average size of less than about 5000 nm, c) contacting said active ingredient or suspension with a first polyelectrolyte during and/or before mechanically treating, d) optionally contacting said suspension with a one or more second or further polyelectrolytes during, before and/or after mechanically treating, e) optionally drying said suspension. The invention also pertains to the pharmaceutical compositions obtained by the method of the invention.
La présente invention concerne un procédé de production dune composition pharmaceutique nanoparticulaire. Le procédé comprend les étapes consistant à a) suspendre dans leau un ingrédient actif faiblement soluble sans la présence dun détergent, b) traiter mécaniquement ladite suspension afin dobtenir des particules comprenant lingrédient actif ayant une taille moyenne effective inférieure à environ 5 000 nm, c) mettre en contact ledit ingrédient actif ou sa suspension avec un premier polyélectrolyte pendant et/ou avant le traitement mécanique, d) éventuellement mettre en contact ladite suspension avec un ou plusieurs second ou plusieurs polyélectrolytes pendant, avant et/ou après le traitement mécanique, e) éventuellement sécher ladite suspension. Linvention concerne également les compositions pharmaceutiques obtenues par le procédé de linvention.
Dunmann Christoph
Gonzales Ferreiro Maria
Kroehne Lutz
Voigt Andreas
Capsulution Pharma Ag
Smart & Biggar
LandOfFree
Improved nanoparticulate compositions of poorly soluble... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Improved nanoparticulate compositions of poorly soluble..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved nanoparticulate compositions of poorly soluble... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1890454