Improved neurospora hosts for the production of recombinant...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/14 (2006.01) C12N 15/01 (2006.01) C12N 15/80 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2240149

The present invention provides improved host cells for use in producing secreted recombinant proteins, methods of making the improved hosts and uses thereof. The invention specifically provides strains of Neurospora crassa which produce reduced levels of extracellular proteases when compared with wild-type Neurospora crassa.

Cette invention porte sur des cellules hôtes améliorées utilisées pour la production de protéines de recombinaison sécrétées, sur des méthodes de production de ces hôtes améliorés et sur les utilisations que l'on en fait. Cette invention a, notamment, trait à des souches de Neurospora crassa produisant des protéases extracellulaires à des niveaux réduits par rapport à la production des Neurospora crassa de type sauvage.

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