Improved nsaid composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/5415 (2006.01) A61K 47/02 (2006.01) A61K 47/14 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2565941

The invention isdirected to a composition and method for treating acute pain using a composition comprising one or more NSAID~s, a metasilicate and optionally a fatty acid ester resulting in increased absorption of poorly soluble active NSAID~s and increased absorption in suppressed vagal systems. The preferred composition comprises meloxicam on a metasilicate matrix; and one or more of the following: sodium bicarbonate, Gelucire®, and tartaric acid.

L'invention se rapporte à une composition et à une méthode de traitement d'une douleur aiguë au moyen d'une composition comportant un ou plusieurs anti-inflammatoires non stéroïdiens (AINS), un métasilicate et éventuellement un ester d'acide gras ayant un effet d'absorption accru des AINS actifs faiblement solubles et d'absorption accrue dans des systèmes vagaux à activité supprimée. La composition préférée comporte du meloxicam sur une matrice de métasilicate, ainsi qu'un ou plusieurs des composés suivants: bicarbonate de sodium, Gelucire®, et acide tartarique.

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