Improved nucleic acids encoding a chimeric glycosyltransferase

Details Improved nucleic acids encoding a chimeric glycosyltransferase Improved nucleic acids encoding a chimeric glycosyltransferase

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2233705

The invention relates to nucleic acids which encode glycosyltransferase and are useful in producing cells and organs from one species which may be used for transplantation into a recipient of another species. It also relates to the production of nucleic acids which, when present in cells of a transplanted organ, result in reduced levels of antibody recognition of the transplanted organ.

L'invention a trait à des acides nucléiques codant une glycolsyltransférase, utiles dans la production de cellules et d'organes d'une espèce pouvant être utilisés en vue d'une greffe chez un receveur d'une autre espèce. Ladite invention a également trait à la production d'acides nucléiques capables de provoquer, lorsqu'ils sont présents dans des cellules d'un organe greffé, une réduction des taux de reconnaissance de l'organe greffé par les anticorps.

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