Improved nucleic acids for reducing carbohydrate epitopes

Details Improved nucleic acids for reducing carbohydrate epitopes Improved nucleic acids for reducing carbohydrate epitopes

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) C12N 5/10 (2006.01) C12N 15/54 (2006.01) C12P 19/18 (2006.01)

Patent

CA 2264952

The invention relates to nucleic acids which encode a first glycosyltransferase which competes with a second enzyme for a substrate, thereby reducing the formation of a product of the second enzyme. The nucleic acids are useful in producing cells and organs with reduced antigenicity and which may be used for transplantation.

L'invention concerne des acides nucléiques codant une première glycosyltransférase concurrente d'une deuxième enzyme afin d'obtenir un substrat, ce qui limite la constitution d'un produit de la deuxième enzyme. Ces acides nucléiques sont utiles pour produire des cellules et des organes présentant un caractère antigénique limité et on peut les utiliser pour des transplantations.

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