A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/16 (2006.01) A61K 38/23 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01) A61K 38/29 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01)
Patent
CA 2430366
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
La biodisponibilité d'agents actifs peptidiques à administrer oralement est améliorée par une composition pharmaceutique conférant une libération ciblée du peptide dans l'intestin, ainsi que par la liaison du peptide actif à un translocateur de membrane pouvant être coupé au moins partiellement in vivo par une enzyme. La composition renferme un excipient de protection résistant aux acides qui transporte les constituants de l'invention à travers l'estomac ; et une quantité suffisante d'un agent diminuant le pH pour réduire le pH intestinal local. Tous les constituants sont libérés ensemble dans l'intestin avec le peptide.
Mehta Nozar M.
Ray Martha V. L.
Stern William
Mccarthy Tetrault Llp
Unigene Laboratories Inc.
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