Improved perfluorocarbons for biological gas exchange and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/025 (2006.01)

Patent

CA 2239170

Perfluorotetramethylcyclohexane shows improved properties for use in biological gas exchange, both as a blood substitute and as perfluorocarbon for intrapulmonary applications. The material has an adequately low vapor pressure to completely avoid causing hyperinflated lung damage and to increase the interval between required applications. However, the compound has a sufficiently high vapor pressure to produce acceptably brief residence time within the body. A method has been developed for using this novel compound to accelerate the exhalation of very low vapor pressure compounds such as perfluorophenanthrene from the lungs. The addition of perfluorotetramethylcyclohexane, along with perfluorophenanthrene, greatly increases the rate at which the perfluorophenanthrene is exhaled.

Cette invention concerne une perfluorotétraméthylcyclohexane offrant de meilleures propirétés et pouvant être utilisé dans l'échange de gaz biologiques, tant en qualité de substitut sanguin qu'en qualité de perfluorocarbone lors d'applications intra-pulmonaires. Cette substance possède une pression de vapeur faible qui permet d'éviter tout risque d'endommagement des poumouns par hyperinflation, et d'allonger l'intervalle entre des applications requises. Ce composé possède toutefois une pression de vapeur qui est assez élevée pour réduire à un niveau acceptable le temps de séjour à l'intérieur du corps. Cette invention concerne également un procédé d'utilisation de ce nouveau composé, lequel procédé permet d'accélérer l'exhalaison depuis les poumons de composés ayant une très faible pression de vapeur, tel que le perfluorophénanthrène. L'addition de perfluorotétraméthylcyclohexane au perfluorophénanthrène permet d'accroître considérablement le rythme d'exhalaison de ce dernier.

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