A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 31/4422 (2006.01)
Patent
CA 2693233
The present invention relates to the formulation of solid dosage forms comprising a therapeutically effective amount of a dihydropyridine calcium channel antagonist such as Lercanidipine or salt thereof, in combination with colloidal silicon dioxide such as Aerosil.TM. to enhance bioavailability and improve solubility, and a process for the preparation thereof by wet granulation.
La présente invention porte sur la formulation de formes posologiques solides comprenant une quantité thérapeutiquement efficace d'un antagoniste de canal calcique de dihydropyridine, tel que la Lercanidipine ou un sel de celle-ci, en combinaison avec un dioxyde de silicium colloïdal tel que AerosilTM pour améliorer la biodisponibilité et améliorer la solubilité, et sur un procédé pour la préparation de celle-ci par granulation à l'état humide.
Iliopoulou Athina
Karavas Evangelos
Koutris Makis
Matsingou Christina
Samara Vicky
Goudreau Gage Dubuc
Pharmathen S.a.
Recordati Ireland Limited
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