Improved pharmaceutical composition containing hmg-coa...

A - Human Necessities – 61 – K

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Details

A61K 31/40 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/404 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2612769

The present invention relates to the formulation of solid dosage forms comprising a therapeutically effective amount of an HMG-CoA reductase inhibitor, and especially Fluvastatin or Atorvastatin or salts thereof, in combination with inorganic silica polymer such as Dimethicone, and a process for the preparation thereof by direct compression.

La présente invention concerne la formulation de formes posologiques solides comprenant une quantité thérapeutiquement suffisante d'inhibiteur de HMG-CoA réductase, et plus particulièrement les fluvastatine ou atorvastatine et certains de leurs sels, en association avec des polymères inorganiques de silice tels que la diméthicone. L'invention concerne également un procédé d'élaboration correspondant par compression directe.

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