Improved polymer-lipid delivery vehicles

Details Improved polymer-lipid delivery vehicles Improved polymer-lipid delivery vehicles

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/51 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2365806

This invention provides a delivery vehicle, said delivery vehicle comprising: (a) a lipid; (b) a hydrophilic polymer conjugated lipid; and, (c) a polymer core, wherein said lipid and hydrophilic polymer conjugated lipid encapsulate the polymer core. Also provided is a method of making a delivery vehicle, said method comprising the steps of (1) dissolving a lipid and a hydrophilic polymer lipid conjugate in a first solvent system; (2) dissolving an active agent and a polymer in a second solvent system; (3) combining the resulting solutions of Steps (1) and (2) and dispersing the resulting mixture by mechanical mixing; (4) removing the organic components of the first and second solvents systems; (5) exchanging the remaining aqueous components of the resulting solution of Step (4) with buffered solution.

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