C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/273 (2006.01)
Patent
CA 2221641
A improved process for preparing 4-hydroxy-2-pyrrolidone of the formula (see formula I) which is characterized in reacting a 4-halogeno-3-hydroxybutyrate and an alkali metal or alkaline earth metal azide, to produce a 4-azido-3-hydroxybutyrate and hydrogenating an azide group of the ester compound and then cyclizing a hydrogenated compound. 4-Hydroxy-2-pyrrolidone is useful for an intermediate of medicines and agricultural chemicals.
L'invention concerne un procédé amélioré pour préparer la 4-hydroxy-2-pyrrolidone représentée par la formule (1), qui est utile comme intermédiaire pour synthétiser des médicaments, des composés utiles en agriculture, etc. Ce procédé consiste à synthétiser un ester de l'acide 4-azido-3-hydroxybutyrique par la réaction d'un ester d'un acide 4-halogéno-3-hydroxybutyrique avec un azoture de métal alcalin ou alcalino-terreux, suivie par la réduction catalytique du groupe azido de l'ester et cyclisation pour obtenir le composé (1).
Furukawa Yoshiro
Nagao Kenichi
Shiomi Yutaka
Daiso Co. Ltd.
Kirby Eades Gale Baker
LandOfFree
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