Improved process for preparing benzimidazole-type compounds

Details Improved process for preparing benzimidazole-type compounds Improved process for preparing benzimidazole-type compounds

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2450433

The present invention relates to an improved process for the preparation of proton pump inhibitors of the benzimidazole-type such as rabeprazole, omeprazole, pantoprazole, lansoprazole and esome prazole, of general formula (1) by oxidation of the corresponding sulfide followed by extraction of the sulfone by-product with an acqueous alkaline solution at controlled pH.

Cette invention concerne un procédé amélioré de préparation d'inhibiteurs de la pompe à protons du type benzimidazole, tels que le rabéprazole, l'oméprazole, le pantoprazole, le lansoprazole et l'ésoméprazole, représentés par la formule générale (I), lequel procédé consiste à oxyder le sulfure correspondant puis à extraire le produit inutile de sulfone au moyen d'une solution alcaline aqueuse à un pH donné.

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