Improved process for preparing cinacalcet hydrochloride

Details Improved process for preparing cinacalcet hydrochloride Improved process for preparing cinacalcet hydrochloride

C - Chemistry, Metallurgy

07

C

C07C 209/68 (2006.01) C07C 211/30 (2006.01)

Patent

CA 2700070

The invention relates to an improved process for preparing cinacalcet hydrochloride. The invention provides an efficient and economic process for preparing cinacalcet hydrochloride which is suitable for industrial implementation i.e., affords cinacalcet hydrochloride with high purity, and uses small volumes of acidifying agent and solvents. The invention also related to a process for preparing a cinacalcet carboxylate salt, including cinacalcet acetate.

L'invention porte sur un procédé perfectionné permettant de préparer du chlorhydrate de cinacalcet. L'invention propose un procédé efficace et économique de préparation de chlorhydrate de cinacalcet qui se prête à une mise en uvre industrielle, à savoir, donne du chlorhydrate de cinacalcet de haute pureté, et utilise de petits volumes d'agent acidifiant et de solvants. L'invention porte également sur un procédé permettant de préparer un sel carboxylate de cinacalcet, y compris l'acétate de cinacalcet.

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