Improved process for preparing gabapentin

Details Improved process for preparing gabapentin Improved process for preparing gabapentin

C - Chemistry, Metallurgy

07

C

C07C 227/18 (2006.01) C07C 227/06 (2006.01) C07C 229/28 (2006.01)

Patent

CA 2650978

A one pot process for preparing l-(aminomethyl)-cyclohexaneacetic acid or pharmaceutically acceptable salts thereof comprises the steps of hydrolysing 1-cyanocyclohexaneacetic acid ethyl ester with a potassium, sodium or lithium hydroxide to form a salt of 1-cyanocyclohexaneacetic acid; in-situ hydrogenating the salt of 1-cyanocyclohexaneacetic acid in the presence of a catalyst to form the salt of l-(aminomethyl)-cyclohexaneacetic acid; and isolating l-(aminomethyl)-cyclohexaneacetic acid.

La présente invention concerne un procédé en récipient unique pour la préparation de l'acide l-(aminométhyl)-cyclohexane acétique ou de ses sels pharmaceutiquement acceptables. Ledit procédé comprend les étapes suivantes: hydrolyse de l'ester éthylique de l'acide 1-cyanocyclohexane acétique à l'aide d'un hydroxyde de potassium, de sodium ou de lithium pour former un sel de l'acide 1-cyanocyclohexane acétique; hydrogénation in situ du sel de l'acide 1-cyanocyclohexane acétique en présence d'un catalyseur pour former le sel de l'acide l-(aminométhyl)-cyclohexane acétique; et isolement de l'acide l-(aminométhyl)-cyclohexane acétique.

Affiliated with

Also associated with

Rating

Improved process for preparing gabapentin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Improved process for preparing gabapentin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved process for preparing gabapentin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1685341