Improved process for producing valproic acid

Details Improved process for producing valproic acid Improved process for producing valproic acid

C - Chemistry, Metallurgy

07

C

C07C 53/126 (2006.01) C07C 51/02 (2006.01) C07C 51/09 (2006.01) C07C 51/41 (2006.01) C07C 67/343 (2006.01)

Patent

CA 2217836

An improved process for producing valproic acid from ethyl acetoacetate is disclosed wherein both the dialkylation of ethylacetoacetate with propyl bromide and the conversion of the dialkylester thus obtained to the corresponding salt take place in a single step, in the presence of a phase-transfer catalyst, in a hydroalcoholic environment, and the salt is converted to valproic acid at pH 1-3.

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