Improved process for synthesizing carbapenem intermediates

C - Chemistry – Metallurgy – 07 – F

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C07F 7/10 (2006.01) C07D 205/08 (2006.01) C07D 477/02 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2224439

A process of synthesizing a compound of formula (1) or (2) is disclosed wherein R represents H or methyl and P represents triethylsilyl or trimethylsilyl. A compound of formula (3) or (4) is reacted with P-C1 wherein P is as defined above, in the presence of base and a substantially non- reactive solvent to produce (1) or (2).

L'invention porte sur un procédé de synthèse d'un composé de formule (1) ou (2), dans lesquelles R représente H ou méthyle et P représente triéthylsilyle ou triméthylsilyle. Un composé de formule (3) ou (4) est amené à réagir avec P-C1, P étant défini comme ci-dessus, en présence d'une base et d'un solvant sensiblement non réactif de façon à donner (1) ou (2).

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